RESUMO
Eosinophilic fasciitis is an uncommon connective tissue disease that may mimic and overlap with other sclerosing disorders such as morphea and lichen sclerosus. Herein, we report four patients (two men and two women, aged 16-64 yeas) with eosinophilic fasciitis. There was overlap with both morphea and lichen sclerosus in 2 patients and with morphoea alone in 1 patient. Magnetic resonance imaging (MRI) was used for diagnosis in three patients and for assessing treatment response in one patient. Eosinophilic fasciitis may co-exist with morhoea and lichen sclerosus. In view of the overlapping clinical and histopathological features of these disorders, MRI may be helful in delineating the conditions by detecting involvement of fascia.
Assuntos
Corticosteroides/administração & dosagem , Imagem Ecoplanar/métodos , Eosinofilia/patologia , Fasciite/patologia , Líquen Escleroso e Atrófico/patologia , Esclerodermia Localizada/patologia , Adolescente , Biópsia por Agulha , Diagnóstico Diferencial , Eosinofilia/diagnóstico , Eosinofilia/tratamento farmacológico , Fasciite/diagnóstico , Fasciite/tratamento farmacológico , Feminino , Seguimentos , Humanos , Imuno-Histoquímica , Líquen Escleroso e Atrófico/diagnóstico , Líquen Escleroso e Atrófico/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Terapia PUVA/métodos , Medição de Risco , Estudos de Amostragem , Esclerodermia Localizada/diagnóstico , Esclerodermia Localizada/tratamento farmacológico , Resultado do TratamentoRESUMO
Morphea is a rare fibrosing disorder of the skin. Evidence-based treatment strategies in morphea are lacking. This review summarizes the available data on morphea treatment and provides therapeutic strategies based on morphea subtypes. The Cochrane Library, Medline and Embase from inception until May of 2011 were searched using the key words "morphea" and "morphea treatment." Reference lists of the resultant articles, as well as relevant reviews, were also searched. This review focuses on randomized controlled trials, prospective interventional trials without controls and retrospective reviews with greater than five subjects.
Assuntos
Algoritmos , Dermatologia/normas , Medicina Baseada em Evidências/métodos , Imunossupressores/uso terapêutico , Esclerodermia Localizada/tratamento farmacológico , Medicina Baseada em Evidências/normas , Humanos , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Secondary mucin deposition in the skin is a common feature of lupus erythematosus and dermatomyositis. In scleroderma, it occurs uncommonly or in small amount. We describe a 7-year-old boy with progressive, linear, bound-down plaques involving the thighs, lower abdomen and back with no systemic involvement. Histopathology showed features of scleroderma with abundant mucin deposition in the reticular dermis. This report highlights excessive mucin deposition in lesions of morphea.